Studies on the Biosynthesis of Nucleic Acids. IV. Synthesis of Labeled 4-Aminoimidazole-5-carboxamide from Barium Carbonate-14C
نویسندگان
چکیده
منابع مشابه
Pharmacological studies on 4 (or 5)-aminoimidazole-5 (or 4)-carboxamide (AICA) derivatives.
In previous works from our laboratory (1-3) we reported that 4-diazoimidazole-5 carboxamide (diazo-ICA) and 4-(mono or di-substituted) triazenoimidazole-5-carboxamide (mono or dialkyl-TICA) showed marked inhibitory effects on the growth of tumors and bacterial cells. During examination of their toxicity in mice, behavioral sedation caused by these compounds was also observed (2). These observat...
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15 صفحه اولRole of 4-aminoimidazole-5-carboxamide in purine synthesis by Escherichia coli.
In a previous communication (1) it has been shown that the accumulation of 4-aminoimidazole-5-carboxamide (“amine”) in sulfadiazine-inhibited Escherichia coli is suppressed by the addition of methionine and catalytic quantities of p-aminobenzoic acid (PABA), and it was assumed that the “labile methyl” group of the sulfur-containing amino acid is used, with the help of PABA as carrier, for the c...
متن کاملRegulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
The present study was undertaken to study the role of AMP-activated kinase (AMPK) in the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Incubation of rat hepatocytes with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), an activator of AMPK, produced dose-dependent inhibition of the incorporation of [(3)H]choline and [(3)H]eth...
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ژورنال
عنوان ژورنال: Pharmaceutical Bulletin
سال: 1956
ISSN: 0369-9471,1881-1345
DOI: 10.1248/cpb1953.4.130